ABSTRACT
Melaleuca alternifolia [tea tree] essential oil has been traditionally used in the ayurvedic system of medicine for healing burns, infections and seborrheic dermatitis. But yet, no controlled human study has determined its efficacy. The goal of the current study was to compare the efficacy of 5% tea tree essential oil [TTO] gel with placebo in the treatment of mild to moderate facial seborrheic dermatitis. Fifty four patients with mild to moderate facial seborrheic dermatitis reffered to Skin Diseases Research Center, in the Qazvin city, Iran, were randomly divided into two groups and treated with either 5% TTO gel or placebo three times daily for 4 weeks. The patients follow-ups were conducted in both groups after 2 and 4 weeks with evaluating of erythema, scaling, itching and greasy crusts. Forty two patients completed the treatment course. There were significant differences between the TTO and placebo groups in the improvement of erythema, scaling, itching and greasy crusts [p < 0.05]. Allergic side - effects were seen in neither group. 5% TTO gel is effective in the treatment of mild to moderate facial seborrheic dermatitis
ABSTRACT
Cinnamomum zeylanicum J. Presl [cinnamon] have been used as food and herbal drug in Asia and Europe. Although some studies have been shown that cinnamon has blood glucose lowering effect but some reports denied it. This study was designed to investigate the efficacy of cinnamon on blood glucose level in patients with type 2 diabetes. This study was a double blind randomized controlled trial study. 61 type 2 diabetic patients with fasting blood glucose of 140 to 250 mg/dl were randomly divided in to two groups. The patients in cinnamon groups received two 500mg cinnamon capsules and patients in placebo group received two 500mg placebo capsules daily. The patients fasting blood glucose, HbA1c, cholesterol, triglyceride, LDL and HDL were determined at starting and after 8 weeks at the end of the study. There was no significant difference in patients fasting blood glucose, HbA1c, cholesterol, triglyceride, LDL and HDL between intervention groups compared with placebo on starting of the trial. Further results indicated that there were no significant difference between two groups regarding lowering of blood glucose, HbA1c, and blood lipids after 8 week of cinnamon and placebo treatment. According to the study results, consumption of one gram of cinnamon per day, do not have blood glucose lowering effects
Subject(s)
Humans , Blood Glucose , Diabetes Mellitus, Type 2 , Plants, Medicinal , Plant Extracts , Double-Blind Method , Randomized Controlled Trials as TopicABSTRACT
In traditional medicine "Crataegus melanocarpa" is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system. Evaluation of Intracerebroventricular [ICV] injection of alcoholic extract of "crataegus melanocarpa" leaves on fear behavior in presence pentylenetetrazole [PTZ] in adult male rat. Animals were divided into 3 groups: experimental, saline and, pentylenetetrazole [PTZ] 20mg/kg as positive control [I.P]. In the experimental group, the animals received 4000 microg/Rat alcoholic extract of "Crataegus melanocarpa" leaves [ICV] and PTZ [I.P]. Then plus maze was used for evaluation of the fear. Open arm entries percentage [%OAE] and open arm time percentage [%OAT] were evaluated. The results show that intracerebroventricular [ICV] injection of alcoholic extract of "Crataegus melanocarpa" leaves increased%OAE and%OAT significantly [p<0.05]. We concluded that alcoholic extract of "Crataegus melanocarpa" is effective on fear reduction in presence pentylenetetrazole [PTZ] in adult male rat